Frailty assessment has come to stay: Retrospective analysis pilot study of two frailty scales in oncological older patients undergoing colorectal surgery.

INTRODUCTION: Colorectal cancer is a disease of the elderly and its main treatment is surgery. Frailty, a clinical syndrome of decreased reserve, increases with age and has been recognized as a predictive factor for postoperative mortality. Our primary objective was to assess the association between two frailty scores and mortality within the first year after surgery, by retrospectively linking frailty scores to mortality data and comparing the strength of their association with mortality to that of the ASA Classification. The frailty scales used were: the Modified Frailty Index (MFI) and, the Risk Analysis Index-A (RAI-A) and the G8 screening test (G8). As secondary objectives, we assessed the relationship of the frailty scales with morbidity and compared all the scales with the ASA. MATERIAL AND METHODS: We retrospectively studied 172 patients aged 65 years and older who underwent laparoscopic colorectal surgery for cancer between January 2017 and June 2018, following them up for 1year after surgery. RESULTS: Both morbidity and mortality were significantly associated with all frailty scale scores (p<.001). The more frailty, the greater probability of prolonged hospital stay, complications, readmissions and emergency department visits. Using each scale, patients were categorized into two groups (frail and non-frail patients). The C-indexes for 1-year mortality with the RAI-A and, MFI and G8 were 0.89 and, 0.86 and 0.86 respectively. On the other hand, ASA status is not strongly associated with mortality, with a C-index of .63. DISCUSSION: Frailty scores should begin to influence medical and surgical strategies and further research is needed to develop guidelines for interventions in geriatric patients.

La evaluación de la fragilidad ha venido para quedarse: Estudio piloto retrospectivo de dos escalas de fragilidad en ancianos oncológicos intervenidos de cirugía colorrectal / Frailty assessment has come to stay: Retrospective analysis pilot study of two frailty scales in oncological older patients undergoing colorectal surgery

Introducción: El cáncer colorrectal es una enfermedad que habitualmente aparece en ancianos y su principal tratamiento continúa siendo quirúrgico. La fragilidad es síndrome clínico que se caracteriza por presentar una disminución de la reserva fisiológica, aumenta con la edad y ha sido reconocido como un factor predictivo de mortalidad postoperatoria. Nuestro objetivo primario ha sido evaluar la asociación entre dos escalas de fragilidad y la mortalidad a un año después de la cirugía, y comparando la fuerza de su asociación del poder predictivo de mortalidad de las escalas de fragilidad y la de la clasificación de la American Society of Anesthesiologists (ASA). Las escalas utilizadas fueron: Modified Frailty Index (MFI) y el Risk Analysis Index (RAI-A). Los objetivos secundarios han sido la evaluación de la relación de las escalas de fragilidad con la morbilidad y la comparación de estas con la clasificación ASA en cuanto a predicción de morbilidad. Material y métodos: Analizamos retrospectivamente 172 pacientes mayores de 65 años que fueron intervenidos de cirugía oncológica colorrectal laparoscópica desde enero de 2017 hasta junio de 2018 con un seguimiento de un año posterior a la cirugía. Resultados: La fragilidad esta significativamente asociada a la mortalidad y morbilidad (p < 0,001). A más fragilidad, mayor probabilidad de estancia hospitalaria, complicaciones, reingresos y visitas a urgencias. Los pacientes fueron categorizados en dos grupos (pacientes frágiles y no frágiles). Los C-index de la predicción a mortalidad a un año obtenidos con el RAI-A y el MFI fueron 0,89 y 0,86, respectivamente. Por otro lado, la clasificación ASA no se relaciona con mortalidad, su C-index fue del 0,63. Discusión: Las escalas de fragilidad deberían empezar a influenciar las intervenciones médicas y quirúrgicas, y se deberían implementar guías y protocolos que tuviesen en cuenta el grado de fragilidad de los pacientes geriátricos.(AU)

Introduction: Colorectal cancer is a disease of the elderly and its main treatment is surgery. Frailty, a clinical syndrome of decreased reserve, increases with age and has been recognized as a predictive factor for postoperative mortality. Our primary objective was to assess the association between twohree frailty scores and mortality. within the first year after surgery, by retrospectively linking frailty scores to mortality data and comparing the strength of their association with mortality to that of the ASA Classification. The frailty scales used were: the Modified Frailty Index (MFI) and, the Risk Analysis Index-A (RAI-A) and the G8 screening test (G8). As secondary objectives, we assessed the relationship of the frailty scales with morbidity and compared all the scales with the ASA. Material and methods: We retrospectively studied 172 patients aged 65 years. and older who underwent laparoscopic colorectal surgery for cancer between January 2017 and June 2018, following them up for 1 year after surgery. Results: Both morbidity and mortality were significantly associated with all frailty scale scores (p < 0.001). The more frailty, the greater probability of prolonged hospital stay, complications, readmissions and emergency department visits. Using each scale, patients were categorized into two groups (frail and non-frail patients). The C-indexes for 1-year mortality with the RAI-A and, MFI and G8 were 0.89 and, 0.86 and 0.86 respectively. On the other hand, ASA status is not strongly associated with mortality, with a C-index of 0.63. Discussion: Frailty scores should begin to influence medical and surgical strategies and further research is needed to develop guidelines for interventions in geriatric patients.(AU)

Afectación cerebrovascular isquémico-hemorrágica en pacientes con covid-19 / Ischemic-hemorrhagic stroke in patients with Covid-19

La infección por el coronavirus asociada al síndrome de distrés respiratorio agudo severo (SARS-CoV-2) produce un síndrome clínico denominado mundialmente covid-19 que ha generado 5.940.441 infectados y 362.813 muertes hasta mayo de 20201. En estadios moderados y severos de la infección se produce una reacción sistémica del organismo caracterizada por la hiperinflamación, tormenta de citocinas y elevación de biomarcadores de daño miocárdico. Además, se ha sugerido la relación entre covid-19 y manifestaciones neurológicas. Recientes autopsias sugieren microangiopatía trombótica en múltiples órganos. Presentamos la descripción de 2 casos de pacientes con covid-19 severo, ingresados en Reanimación, que presentaron afectación cerebrovascular y fallecieron posteriormente. Se recomienda estrictamente la aplicación de profilaxis farmacológica antitrombótica en los pacientes afectados por covid-19 ingresados en cuidados críticos y se sugiere administrar dosis profilácticas por encima de la media

Coronavirus associated severe acute respiratory syndrome (SARS-CoV-2) causes a worldwide syndrome called Covid-19 that has caused 5,940,441 infections and 362,813 deaths until May 2020. In moderate and severe stages of the infection a generalized swelling, cytokine storm and an increment of the heart damage biomarkers occur. In addition, a relation between Covid-19 and neurological symptoms have been suggested. The results of autopsies suggest thrombotic microangiopathy in multiple organs. We present 2 cases of patients infected with severe Covid-19 that were hospitalized in the Reanimation Unit that presented cerebrovascular symptoms and died afterwards. A high dose prophylaxis with antithrombotic medication is recommended in patients affected by moderate to severe Covid-19

Ischemic-hemorrhagic stroke in patients with Covid-19. / Afectación cerebrovascular isquémico-hemorrágica en pacientes con covid-19.

Coronavirus associated severe acute respiratory syndrome (SARS-CoV-2) causes a worldwide syndrome called Covid-19 that has caused 5,940,441 infections and 362,813 deaths until May 2020. In moderate and severe stages of the infection a generalized swelling, cytokine storm and an increment of the heart damage biomarkers occur. In addition, a relation between Covid-19 and neurological symptoms have been suggested. The results of autopsies suggest thrombotic microangiopathy in multiple organs. We present 2 cases of patients infected with severe Covid-19 that were hospitalized in the Reanimation Unit that presented cerebrovascular symptoms and died afterwards. A high dose prophylaxis with antithrombotic medication is recommended in patients affected by moderate to severe Covid-19.

Native valve infective endocarditis due to ampicillin-resistant Escherichia coli in the postoperative period of a right radical nephrectomy due to xanthogranulomatous pyelonephritis. / Endocarditis infecciosa sobre válvula nativa por Escherichia coli resistente a ampicilina en el postoperatorio de una nefrectomía radical derecha por pielonefritis xantogranulomatosa.

Infective endocarditis (IE) due to Escherichia coli is a rare disease, although increasingly frequent. Persistent fever in septic patients despite adequate treatment raises the need to consider IE as a differential diagnosis. We present the case of a 36-year-old male patient who underwent a radical right nephrectomy as a result of diagnosis of xanthogranulomatous pyelonephritis, presenting in the postoperative period a state of septic shock with persistent fever of 41°C. Given the finding of a new-onset murmur, he was diagnosed with a mitroaortic IE by means of a transesophageal echocardiogram (TEE), having to undergo cardiac surgery for valve replacement. After multiple postoperative complications, he is successfully discharged.

Parálisis diafragmática unilateral tras colecistectomía laparoscópica / Unilateral diaphragmatic paralysis after laparoscopic cholecystectomy

La colecistectomía laparoscópica supone hoy en día el tratamiento gold estándar de la patología aguda de la vía biliar. A pesar de las numerosas ventajas que presenta respecto a la cirugía abierta clásica, no está exenta de complicaciones. Presentamos el caso de un paciente varón de 82 años que tras el diagnóstico de colecistitis gangrenosa es intervenido de urgencia de colecistectomía laparoscópica, presentando en las primeras 24h del postoperatorio un episodio de insuficiencia respiratoria aguda, motivo por el cual ingresa en reanimación. Los estudios realizados a posteriori mostraron una parálisis del hemidiafragma derecho, probablemente relacionada con la cirugía

Laparoscopic cholecystectomy is currently the gold standard treatment for acute biliary tract pathology. Despite its many advantages compared to open surgery, it is not without complications. We present the case of an 82-year-old man who, after a diagnosis of gangrenous cholecystitis, underwent urgent laparoscopic cholecystectomy. During the first 24hours after the surgery, he had an episode of acute respiratory failure, for which he was admitted to the critical care unit. Studies performed later showed paralysis of the right diaphragm that was probably related to the surgery

Unilateral diaphragmatic paralysis after laparoscopic cholecystectomy. / Parálisis diafragmática unilateral tras colecistectomía laparoscópica.

Laparoscopic cholecystectomy is currently the gold standard treatment for acute biliary tract pathology. Despite its many advantages compared to open surgery, it is not without complications. We present the case of an 82-year-old man who, after a diagnosis of gangrenous cholecystitis, underwent urgent laparoscopic cholecystectomy. During the first 24hours after the surgery, he had an episode of acute respiratory failure, for which he was admitted to the critical care unit. Studies performed later showed paralysis of the right diaphragm that was probably related to the surgery.

Síndrome de Kounis tras administración de rocuronio / Kounys syndrome after rocuronium administration

El síndrome de Kounis engloba conceptos entre los que se incluyen la angina e infarto alérgico descritos en relación con la exposición a diferentes alérgenos. El objetivo de este artículo es describir un caso de síndrome de Kounis tipo II tras la exposición a rocuronio así como la fisiopatología y tratamiento de este síndrome

Kounis syndrome encompasses concepts including angina and allergic infarction described in relation to exposure to different allergens. The aim of this article is to describe a case of Kounis Syndrome type II after exposure to rocuronium as well as the patholophysiology and the treatment of this syndrome

Kounys syndrome after rocuronium administration. / Síndrome de Kounis tras administración de rocuronio.

Kounis syndrome encompasses concepts including angina and allergic infarction described in relation to exposure to different allergens. The aim of this article is to describe a case of Kounis Syndrome type II after exposure to rocuronium as well as the patholophysiology and the treatment of this syndrome.

Aclaración sobre el manejo perioperatorio de los IECA y ARA-II / Comment on perioperative managment of ACE inhibitors and ARBs

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Aplicación clínica de los principios farmacocinéticos y farmacodinámicos en anestesia total intravenosa / No disponible

Para obtener una anestesia adecuada, reduciendo el riesgo de toxicidad farmacológica sin comprometer la eficacia, es necesario conocer la evolución temporal de las concentraciones del fármaco en el organismo (farmacocinética), así como la relación que existe entre esta y el efecto (farmacodinamia). Los conceptos farmacocinéticos y farmacodinámicos son la base para la aplicación de los sistemas de infusión utilizados ampliamente en anestesia intravenosa. Es necesario comprender algunos de estos conceptos para poder entender como funcionan los sistemas de infusión abiertos (TCI), como cerrados (sistemas de asa cerrada). Este trabajo pretende explicar brevemente algunos de estos conceptos, como son la teoría de los modelos compartimentales, el concepto de vida media dependiente del contexto, Keo o la ventana terapéutica, que posteriormente se desarrollan en la descripción del funcionamiento de estos sistemas

To obtain an appropriate anesthesia, reducing the risk of pharmacologic toxicity without affecting efficacy, it is necessary to know the chronological evolution of the drug concentrations in the organism (pharmacokinetics) and the relation between this one and the effect (pharmacodynamics). The pharmacokinetic and pharmacodynamic concepts are the basis for applicating the infusion systems widely used in intravenous anesthesia. It is essential to know some of these ideas to be able to comprehend how these infusion systems work, both open systems (TCI) and closed systems (closed loop systems) This article tries briefly to explain some of these concepts, like compartimental model theory, Context Sensitive Half Life, Keo and therapeutic window. These notions will be explained further in the description of the working of these systems

Síndrome de QT prolongado y anestesia regional. A propósito de un caso / Prolonged QT syndrome and regional anesthesia: a case report

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